The Center of Extracorporeal hemocorrection. High efficiency at treatment: Clamidiosis, Ureaplasmosis, Mycoplasmosis and other chronic infectious processes of urinogenital sphere, female sterility due to an antiphospholipid syndrome.
Extracorporeal and drug methods of treating the gynecological diseases
The developed technologies of Extracorporeal Hemocorrection make it possible to considerably improve the results of treating the number of the diseases of urogenital sphere.So - complete recovery Clamidiosis is succeeded in attain in 9 cases of 10
This is reached due to:
- Considerably the more effective, in comparison with the usual, methods of Extracorporeal Immunopharmacotherapy, which make it possible in short periods to restore the state of the immunological protection of the organism
- of the technologies of the directed transport of the medicines, which give the possibility to deliver antibacterial preparations directly into the centers of chronic infectious inflammation and, is assuredly, to choke the activity of infectious process, to the minimum after lowering, in this case, the negative side effects of antibiotics for the organism of the patient
The application of technologies of extracorporeal hemocorrection with the treatment of the diseases of genital organs and disturbances of the reproductive function
Clamydia relate to the agents, most frequently transmitting through sex. Not less than 10 - 20% of young sexually active people are struck by khlamidiynoy infection. The consequence of the vital activity of these microorganisms, it is the development of chronic inflammatory processes, the damaging different divisions of urogenital'nogo circuit both in the men and in women. Such illnesses, as chronic prostatitis, chronic urethritis – at men, endometritis and chronic inflammatory processes of appendages - in women, frequently prove to be those caused by precisely khlamidiynoy infection. Khlamidii are revealed in each second woman with the chronic inflammatory diseases of urogenital'noy sphere and in 57% of women, who suffer sterility. The frequent reason for man sterility are also clamydia.
The traditional drug therapy of the chronic inflammatory diseases of urogenital sphere, caused by chlamydial infection meets with formidable difficulties. These difficulties are defined both by the special feature of these microorganisms, which are consisted in the specific intracellular multiplication of chlamydia, and, by frequently associating, by immunodeficiency. The intracellular multiplication of microorganisms considerably limits the possibilities of usual antibacterial therapy. Indeed the majority of the antibacterial preparations, which act precisely on the young dividing forms of microorganisms, are incapable to penetrate in the cell. In this case the inflammatory barrier, which is created around the centers of chronic infection, even to the larger degree hampers the action of antibiotics. And the reduced potential of immunological protection does not allow an organism to generate itself the adequate response to the introduction of infection.
For the purpose of an increase in the effectiveness in the treatment of clamidiosis is at present developed the comprehensive program, whose basis compose the methods of Extracorporeal hemocorrection.
The program of treatment includes 4 - 5 sessions of extracorporeal hemocorrection, conducted with the interval during 1 - 2 days.
The technologies of the Incubation of cellular mass with the antibiotics, which make it possible to create the effective concentrations of antibacterial preparations, in the infectious centers are used for the purpose of the sanitation of the center of infection. About the effectiveness of these technologies of antibacterial therapy we more than once spoke on the pages of this site. These technologies, with the same clinical effect, make it possible to reduce the course dose of antibiotic 4 - 8 times, and it means - to decrease the negative action of antibacterial preparations on the organism of patient.
The damaging action of antibiotics on the functional activity of immune system already is long ago proven. I.e., with the usual drug therapy, the attempts to choke the activity of infectious process by the growth of the doses of antibiotics - often lead to the development of expressed immunodeficiency, and after end of the course of antibacterial therapy organism proves to be defenseless before the bacterial aggression.
The application of programs of extracorporeal hemocorrection makes it possible not only not to descend the activity of immune system, but on the contrary - to restore its disrupted functions.
For the purpose of the restoration of the immunological protection of organism by us adapt the methods of Extracorporeal Immunopharmacotherapy. In essence the methods of the incubation of leukocyte mass with the immunomodulators. It is known that with extracellular existence of clamydia in the form of elementary corpuscles they are not sensitive to the antibiotics, but they are sensitive to the antibodies, cytokines, interferon, interleukines. It is proven that clamydial infection, although is caused the production of interferon (similar to virus infections), it is far insufficient for the destruction of microorganism. In connection with this we use the inductors of interferons with the treatment of clamidiosis.
Thus, the program application of methods of extracorporeal hemocorrection is allowed: from one side - to effectively choke the centers of infection, with another - to restore the immunological potential of organism, allowing for it subsequently to effectively manage the bacterial aggression.
Technologies of extracorporeal hemocorrection enumerated above are supplemented with the methods of the wave working of the blood, which with the chronic inflammatory processes are capable of considerably improving microcirculation in the stricken area, increasing in this case the nonspecific resistance of organism.
The obtained practical clinical results attest to the fact that the extracorporeal methods of treating the urogenital intracellular infection (clamidiosis) are more significant more effective than the traditional conservative therapy.
Application of a comprehensive program of treatment,developed at present:
- considerably is reduced a quantity of relapses of the chronic inflammatory diseases of internal genital organs,
- in 40% of patients with the sterility it contributes to the restoration of reproductive function,
- 2,5 times it makes it possible to accelerate stopping the syndrome of endogenous intoxication,
- 5,4 it decreases the frequency of candidal vulvovaginitis and disturbances of microbiocenosis of vagina,
- in this case the elimination of clamydia (according to the data of PCR) is achieved in 91,5% of cases.
With conducting of the standard therapy, which includes 2 courses of the antibacterial, desensitizing therapy, physical therapy and local treatment the sanitation of organism from clamydia is achieved only in 49%. Furthermore, the standard therapy of clamidiosis, as we already spoke above, has deficiencies, connected with the application of large doses of antibiotics.
Female sterility of autoimmune genesis
Anti-phospholipid syndrome – disease of the autoimmune genesis, with which occurs the production of antibodies to the specific, widespread phospholipid determinants, which be present on the membranes of the cells of different tissues. The manifestation of this disease it is sufficiently diverse. Us in this case had interest the disturbances of reproductive function the women, caused by the development of anti-phospholipid syndrome.
According to literature data anti-phospholipid syndrome is the reason for noncarrying of pregnancy into 10 - 40% of cases. The role of anti-phospholipid antibodies (aFL) in the pathogenesis of the undeveloped pregnancy is proven in 90-95% of women.
The mechanisms of the termination of pregnancy with the anti-phospholipid syndrome are reduced in essence to the disturbances in the system of coagulation of the blood, progressive because of this processes of thrombogenesis and the formation of hemorrhages into the region of the fastening of embryo, and to the development of placental insolvency. These disturbances are determined in 50 - 60% of women with the anti-phospholipid syndrome.
They serve as the criteria of diagnostics of anti-phospholipid syndrome in women:
- the high level of antibodies to cardiolipin (more than 20 FL unit.
- spontaneous abortion with the period of 10 weeks and more
- neonatal death of morphologically normal newborn because of gestoza or placental insufficiency
- 3 spontaneous abortions in the pre embryonal or early embryonal stages
The traditional drug therapy of anti-phospholipid syndrome includes:
- the application of corticosteroids for the purpose of the suppression of the production of antibodies (possible complications: osteoporosis, premature discharge of amniotic fluid, premature labor, the development of the ascending infection, the gestational diabetes, the congenital hypoplasia of the adrenal glands in newborns)
- the application of low doses of aspirin for the balancing of system prostacyclin- thromboxane (possible complications: the ulcerogenic and capillarotoxic action)
- the small doses of heparin or other anticoagulant for the correction of hyper-coagulation syndrome (under a strict laboratory control)
- Gamma globulin - intravenous introduction for the blocking of autoantibodies to the phospholipids with thrombocytopenia and the resistance to the corticosteroids
At the same time the effectiveness of the traditional drug therapy of the disturbances of reproductive function in women remains low.
For the purpose of an increase in the effectiveness in the treatment of this illness at present by the association of Siberian researchers (V.M. Kreynes, S.V. Vlasov, N.V. Yakovleva) is developed the Program of the application of methods of extracorporeal hemocorrection.
This program it is based on the algorithm, built on the calculation of the existing clinical laboratory indices, which reflect the pathogenetic special features of disease in concrete patient. Depending on the prevailing pathogenetic mechanisms, the program includes either the technologies of Extracorporeal cryomodification of autoplazma or Extracorporeal thermomodification of autoplazma.
Each of these technologies of extracorporeal hemocorrection makes it possible to solve their spectrum of tasks.
So the technology of the cryomodification of autoplasma gives the possibility to decrease the concentration of specific autoaggressive antibodies, to improve the rheological parameters of the blood, to decrease the aggregative activity of erythrocytes and thrombocytes, to eliminate the circulating immune complexes, to increase endothelial-dependent vasodilation and to improve placental blood flow.
The application of technology of the thermomodification of autoplasma allows, in turn, to practically completely remove fibrinogen from modified autoplazma and to 30% to decrease in the blood of patient the concentration of the products of his disrupted metabolism, on 21 - 24% to increase the fibrinolytic activity of the blood, to 15 - 18% to decrease the viscosity of the blood, it is more than to 30% to decrease the activity of the factors of coagulation and on to increase the anti-coagulation potential of the blood.
All these effects as a whole made it possible in 100% of cases to dilute the manifestation of thrombohemorrhagic syndrome and they contributed to the retention of pregnancy in all patients. The comparative estimation of effectiveness in the traditional drug therapy and program application of methods of extracorporeal hemocorrection is illustrated in figures 1 and 2.
Fig. 1. Frequency of the offensive of pregnancy in women with the anti-phospholipid syndrome during
the traditional drug therapy and the program application of methods of extracorporeal hemocorrection.
the traditional drug therapy and the program application of methods of extracorporeal hemocorrection.
Fig. 2. Stopping thrombohemorrhagic syndrome in patients with the anti-phospholipid syndrome during the traditional drug therapy and the program application of methods of extracorporeal hemocorrection.
The given results show considerably higher efficiency. In this case during the application of data of the technologies of Extracorporeal hemocorrection it was not observed the significant complications.
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